ESX1 Antibody Summary
Antibody was raised against a 19 amino acid peptide near the center of human ESX1
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Immunogen affinity purified
- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Immunocytochemistry/Immunofluorescence 20 ug/ml
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:10-1:500
Alternate Names for ESX1 Antibody
- ESX homeobox 1
- ESX1-related protein
- ESXR1homeobox protein ESX1
- extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)
- extraembryonic, spermatogenesis, homeobox 1 homolog
- Extraembryonic, spermatogenesis, homeobox 1
Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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