ESX1 Antibody

Images

 
Western Blot: ESX1 Antibody [NBP1-77114] - Human testis tissue lysate with ESX1 antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: ESX1 Antibody [NBP1-77114] - Immunofluorescence of ESX1 in human testis tissue with ESX1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: ESX1 Antibody [NBP1-77114] - Human testis tissue with ESX1 antibody at 2.5 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ESX1 Antibody Summary

Immunogen
Antibody was raised against a 19 amino acid synthetic peptide near the center of human ESX1. The immunogen is located within amino acids 140 - 190 of ESX1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ESX1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
ESX1 Peptide (NBP1-77114PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ESX1 Antibody

  • ESX homeobox 1
  • ESX1LESX1R
  • ESX1-related protein
  • ESXR1homeobox protein ESX1
  • extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)
  • extraembryonic, spermatogenesis, homeobox 1 homolog
  • Extraembryonic, spermatogenesis, homeobox 1

Background

Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the homeodomain and the proline-rich domain. During embryogenesis, ESX1 is expressed in the extraembryonic tissues, including the endoderm of the visceral yolk sac, the ectoderm of the chorion and the labyrinthine trophoblast of the chorioallantoic placenta. ESX1 can act like a transcriptional repressor to the human oncogene K-ras and treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorgenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic treatment for these cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ESX1
Uniprot