ERK5/BMK1 Antibody

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Western Blot: ERK5/BMK1 Antibody [NBP1-42673] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-ERK5 antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.2 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

ERK5/BMK1 Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 766 and 816 of human extracellular-signal-regulated kinase 5 using the numbering given in entry NP_002740.2 (GeneID 5598).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MAPK7
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 2-5 ug/mg lysate
Reviewed Applications
Read 1 Review rated 5
using
NBP1-42673 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ERK5/BMK1 Antibody

  • Big MAP kinase 1
  • BMK1 kinase
  • BMK1
  • BMK-1
  • BMK1EC 2.7.11.24
  • EC 2.7.11
  • ERK5
  • ERK-5
  • ERK5MAPK 7
  • Extracellular signal-regulated kinase 5
  • extracellular-signal-regulated kinase 5
  • MAP kinase 7
  • MAPK7
  • mitogen-activated protein kinase 7
  • PRKM7ERK4

Background

The extracellular signal-regulated kinase 5 (ERK5), also known as MAPK7 or big mitogen-activated protein kinase 1 (BMK1), is a member of the MAP kinase subfamily (1). ERK5 differs considerably from other MAPKs; it contains an unusually long carboxyl-terminal tail which might contribute to the regulation of its activity and/or localization. In response to extracellular signals, ERK5 translocates to the nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors (2). ERK5 also differs from other MAPKs in possessing a potent transcriptional activation domain which mediates protein-protein interactions with the myocyte enhancer factor 2 (MEF2) transcription factors (3). ERK5 is specifically activated by MAPK kinase 5 (MAP2K5/MEK5) and plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for ERK5/BMK1 Antibody (NBP1-42673) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: WB.

Reviews using NBP1-42673:
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Images Ratings Applications Species Date Details
Western Blot ERK5/BMK1 NBP1-42673
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reviewed by:
Anonymous
WB Human 03/27/2014
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Summary

ApplicationWestern Blot
SpeciesHuman
LotA1
FileView PDF

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Recent Reviews

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Anonymous
03/27/2014
Application: WB
Species: Human

Bioinformatics

Gene Symbol MAPK7
Entrez