ERK5/BMK1 Products

Antibodies
ERK5/BMK1 Antibody [Unconjuga ...
ERK5/BMK1 Antibody [Unconjugated]
AF2848
Species: Hu, Mu
Applications: WB, ICC
Host: Goat Polyclonal
ERK5/BMK1 Antibody
ERK5/BMK1 Antibody
NBP1-42673
Species: Hu, Mk, Pm
Applications: WB, IP
Host: Rabbit Polyclonal
ERK5/BMK1 Antibody (3H2)
ERK5/BMK1 Antibody (3H2)
NBP2-03371
Species: Hu
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Lysates
ERK5/BMK1 Overexpression Lysa ...
ERK5/BMK1 Overexpression Lysate (N...
NBL1-12882
Applications: WB
ERK5/BMK1 Overexpression Lysa ...
ERK5/BMK1 Overexpression Lysate (N...
NBL1-12879
Applications: WB
Proteins
Recombinant Human ERK5/BMK1 P ...
Recombinant Human ERK5/BMK1 Protein
H00005598-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human ERK5/BMK1 P ...
Recombinant Human ERK5/BMK1 Protein
H00005598-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
ERK5/BMK1 RNAi
ERK5/BMK1 RNAi
H00005598-R05
Species: Hu
Applications: RNAi, RNAi SP
ERK5/BMK1 RNAi
ERK5/BMK1 RNAi
H00005598-R08
Species: Hu
Applications: RNAi, RNAi SP
ERK5/BMK1 RNAi
ERK5/BMK1 RNAi
H00005598-R07
Species: Hu
Applications: RNAi, RNAi SP

Description

The extracellular signal-regulated kinase 5 (ERK5), also known as MAPK7 or big mitogen-activated protein kinase 1 (BMK1), is a member of the MAP kinase subfamily (1). ERK5 differs considerably from other MAPKs; it contains an unusually long carboxyl-terminal tail which might contribute to the regulation of its activity and/or localization. In response to extracellular signals, ERK5 translocates to the nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors (2). ERK5 also differs from other MAPKs in possessing a potent transcriptional activation domain which mediates protein-protein interactions with the myocyte enhancer factor 2 (MEF2) transcription factors (3). ERK5 is specifically activated by MAPK kinase 5 (MAP2K5/MEK5) and plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development (4-5).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5598
Alternate Names
  • ERK-5
  • EC 2.7.11
  • BMK-1
  • extracellular-signal-regulated kinase 5
  • Extracellular signal-regulated kinase 5
  • BMK1 kinase
  • Big MAP kinase 1
  • PRKM7ERK4
  • BMK1EC 2.7.11.24
  • ERK5MAPK 7
  • MAP kinase 7
  • mitogen-activated protein kinase 7

Pathways for ERK5/BMK1

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
Cell Cycle
Cell Growth
Regeneration
Cell Division
Stem Cell Proliferation
Cell Motility
Mitosis
Lipoxygenase Pathway
Pathogenesis
Cell Maturation

Research Areas for ERK5/BMK1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific
Signal Transduction

PTMs for ERK5/BMK1

Learn more about PTMs related to ERK5/BMK1.

Phosphorylation
Dephosphorylation

Bioinformatics Tool for ERK5/BMK1

Discover related pathways, diseases and genes to ERK5/BMK1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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