ER beta/NR3A2 Antibody (7B10.7)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ChIP, IP
Clone
7B10.7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

ER beta/NR3A2 Antibody (7B10.7) Summary

Immunogen
Amino acids 1-153 of human ER expressed in E. coli.
Localization
Nuclear
Specificity
This antibody will recognize human ER beta.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ESR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-5 ug/ml
  • Chromatin Immunoprecipitation 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
Application Notes
ChIP usage reported in scientific literature. WB: Predicted MW is 59 kDa.
Theoretical MW
59 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP1-41194 in the following applications:

  • 9 publications

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for ER beta/NR3A2 Antibody (7B10.7)

  • ER beta
  • Erb
  • ER-beta
  • ESR2
  • ESR-BETA
  • ESTRB
  • estrogen receptor 2 (ER beta)
  • estrogen receptor beta 4
  • estrogen receptor beta
  • NR3A2
  • NR3A2ESRB
  • Nuclear receptor subfamily 3 group A member 2

Background

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE's).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ER beta/NR3A2 Antibody (NBP1-41194)(9)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ChIP.


Filter By Application
ChIP
(9)
All Applications
Filter By Species
Human
(9)
All Species
Showing Publications 1 - 9 of 9.
Publications using NBP1-41194 Applications Species
Vivar OI, Zhao X, Saunier EF et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem 2010 Jul [PMID: 20404318] (ChIP, Human) ChIP Human
Vivar OI, Saunier EF, Leitman DC et al. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology 2010 Apr [PMID: 20160136] (ChIP, Human) ChIP Human
Charn TH, Liu ET, Chang EC et al. Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection. Mol Endocrinol 2010 Jan [PMID: 19897598] (ChIP, Human) ChIP Human
Chang EC, Charn TH, Park SH et al. Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol 2008 May [PMID: 18258689] (ChIP, Human) ChIP Human
Cvoro A, Paruthiyil S, Jones JO et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology 2007 Feb [PMID: 17095596] (ChIP, Human) ChIP Human
Cvoro A, Tzagarakis-Foster C, Tatomer D et al. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell 2006 Feb [PMID: 16483936] (ChIP, Human) ChIP Human
Tee Primate, Rogatsky I, Tzagarakis-Foster C et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell 2004 Mar [PMID: 14699072] (ChIP, Human) ChIP Human
Bianco NR, Perry G, Smith MA et al. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Mol Endocrinol 2003 Jul [PMID: 12714703] (ChIP, Human) ChIP Human
Burakov D, Crofts LA, Chang CP et al. Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. J Biol Chem 2002 Apr [PMID: 11893728] (ChIP, Human) ChIP Human

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Product General Protocols

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Video Protocols

WB Video Protocol
ChIP Video Protocol
ChIP Webinar

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ESR2
Entrez