EphA7 Antibody [HRP]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: HRP

EphA7 Antibody [HRP] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse EphA7 isoform 1
  Ala30-Pro554 (Gly540-Glu544 del)
  Accession # Q61772
• Specificity: Detects mouse EphA7 in direct ELISAs and Western blots. In direct ELISAs, approximately 2% cross‑reactivity with recombinant mouse (rm) EphA3 is observed and less than 1% cross-reactivity with rmEphA2, rmEphA4, rmEphA6, and rmEphA8 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: EPHA7
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Alternate Names for EphA7 Antibody [HRP]

• Cek11
• Ebk
• EC 2.7.10
• EC 2.7.10.1
• Ehk3
• EHK-3
• EK11
• EPH homology kinase 3
• Eph homology kinase-3
• EPH receptor A7
• EphA7
• EPH-like kinase 11
• ephrin type-A receptor 7
• Hek11
• Mdk1
• receptor protein-tyrosine kinase HEK11
• tyrosine-protein kinase receptor EHK-3

Background

The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8(Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5(Hek9) and EphB6 (Mep). EphAs are a family of receptor tyrosine kinases that are involved in axonal guidance during development. These receptors and their ligands, the ephrins, act via repulsive mechanisms to guide growing axons towards their appropriate targets and allow for the correct developmental connections to be made. Ligand binding to an Eph receptor results in tyrosine phosphorylation of the kinase domain, and repulsion of axonal growth cones and migrating cells. During neurulation, ephrin-A5 is coexpressed with its cognate receptor EphA7 in cells at the edges of the dorsal neural folds. Three different EphA7 splice variants, a full-length form and two truncated versions lacking kinase domains, are expressed in the neural folds.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EPHA7