EphA3 Antibody

Product Discontinued

EphA3 Antibody Summary

• Immunogen: This antibody was made against a protein fragment from the Middle Region
• Specificity: This product is specific for Human EPHA3.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: EPHA3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:5000-1:20000
• Application Notes: This antibody is useful in ELISA and Western Blot.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs. These products are available in limited quantities. Please enquire about the availability of this product before purchasing.

Alternate Names for EphA3 Antibody

• Cek4
• EC 2.7.10
• EC 2.7.10.1
• EK4
• EPH receptor A3
• EphA3
• EPH-like kinase 4
• ephrin type-A receptor 3
• ETK
• Hek4
• HEKETK1eph-like tyrosine kinase 1
• human embryo kinase 1
• TYRO4 protein tyrosine kinase
• Tyro4
• Tyrosine-protein kinase receptor ETK1
• Tyrosine-protein kinase TYRO4

Background

Ephrin receptor tyrosine kinases (RTKs) and their ligands (ephrins) are highly conserved families which mediates cell movement during development (1). There are 14 known receptors, classed into either EphA or EphB, and 8 known ligands, classed into ephrin A or ephrin B. EphA receptors preferably interacts with glycosylphosphatidylinositol-linked ephrins (ephrin A), while EphB receptors preferably interacts with transmembrane ligands (ephrin B) (2). Multiple ligands are specific to each Ephrin receptors and cause receptor activation through transphosphorylation (3, 4). Both receptor and ligand-initiated signals can regulate repulsion, adhesion and de-adhesion mechanisms for the motility of adherent cells (5). Ephrin A3 (EphA3, Mek4, Hek, Hek4) binds to ephrin-A1 to A5 and ephrin-B1. A somatic mutation on EphA3 gene has been linked to pathogenesis to several tumors, such as breast, lung, and pancreatic cancers (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for EphA3 Antibody (36140002)(2)

Publications using 36140002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

FAQs for EphA3 Antibody (36140002). (Showing 1 - of FAQs).

Bioinformatics

• Gene Symbol: EPHA3
• Entrez:
  • 2042(Human)
• Uniprot:
  • P29320(Human)