EphA3 Antibody (6C1B6)

Western Blot: EphA3 Antibody (6C1B6) [NBP1-47420] - Analysis using EphA3 mouse mAb against truncated Trx-EphA3 recombinant protein (1) and truncated EphA3(aa566-983)-hIgGFc transfected CHO-K1 cell lysate(2).

Product Discontinued

EphA3 Antibody (6C1B6) Summary

• Immunogen: Purified recombinant fragment of EphA3 (aa751-983) expressed in E. Coli.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: EPHA3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Western Blot 1: 500 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.03% Sodium Azide
• Purity: Unpurified

Alternate Names for EphA3 Antibody (6C1B6)

• Cek4
• EC 2.7.10
• EC 2.7.10.1
• EK4
• EPH receptor A3
• EphA3
• EPH-like kinase 4
• ephrin type-A receptor 3
• ETK
• Hek4
• HEKETK1eph-like tyrosine kinase 1
• human embryo kinase 1
• TYRO4 protein tyrosine kinase
• Tyro4
• Tyrosine-protein kinase receptor ETK1
• Tyrosine-protein kinase TYRO4

Background

Ephrin receptor tyrosine kinases (RTKs) and their ligands (ephrins) are highly conserved families which mediates cell movement during development (1). There are 14 known receptors, classed into either EphA or EphB, and 8 known ligands, classed into ephrin A or ephrin B. EphA receptors preferably interacts with glycosylphosphatidylinositol-linked ephrins (ephrin A), while EphB receptors preferably interacts with transmembrane ligands (ephrin B) (2). Multiple ligands are specific to each Ephrin receptors and cause receptor activation through transphosphorylation (3, 4). Both receptor and ligand-initiated signals can regulate repulsion, adhesion and de-adhesion mechanisms for the motility of adherent cells (5). Ephrin A3 (EphA3, Mek4, Hek, Hek4) binds to ephrin-A1 to A5 and ephrin-B1. A somatic mutation on EphA3 gene has been linked to pathogenesis to several tumors, such as breast, lung, and pancreatic cancers (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for EPH Receptor A3 Antibody (NBP1-47420). (Showing 1 - of FAQ).

Bioinformatics

• Gene Symbol: EPHA3
• Entrez:
  • 2043(Human)