Endothelin-3 Antibody

Product Discontinued

Endothelin-3 Antibody Summary

• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 17-238 of human Endothelin-3 (NP_996917.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: EDN3
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 50% glycerol, pH7.3.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Endothelin-3 Antibody

• EDN3
• endothelin 3
• Endothelin3
• Endothelin-3
• ET3
• ET-3
• HSCR4
• MGC15067
• MGC61498
• PPET3
• preproendothelin-3
• truncated endothelin 3
• WS4B

Background

Endothelin 3 is encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: EDN3