Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Immunogen affinity purified
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for EDA2R/TNFRSF27/XEDAR Antibody
ectodysplasin A2 receptor
EDAA2Rtumor necrosis factor receptor superfamily member XEDAR
XEDARTNFRSF27tumor necrosis factor receptor superfamily member 27
X-linked ectodysplasin-A2 receptor
X-linked ectodysplasin receptor (XEDAR) is a type III transmembrane that lacks an N-terminal signal peptide. It is an X-linked member of the TNF Receptor Superfamily (TNFRSF). Human XEDAR is a 297 amino acid (aa) protein with a 136 aa extracellular domain, a 21 aa transmembrane domain, and a 140 aa cytoplasmic domain. Within the TNFRSF, XEDAR shares the highest homologies with EDAR and TNFRSF19/TROY. EDA-A2 is the XEDAR ligand. XEDAR expression is principally found in embryonic hair follicles. XEDAR, EDAR, EDA-A1 and EDA-A2 have been associated with hypohidrotic ectodermal dysplasia (HED). HED is characterized by abnormalities in hair, teeth, and eccrine sweat gland morphogenesis. HED was initially found to associate with two gene loci, tabby and downless. Tabby was later identified as the gene for EDA and downless as the autosomal EDAR gene. EDA has two splice variants, EDA-A1 and EDA-A2 which differ by only two amino acids. Despite this minor difference, the EDA isoforms display strong receptor specificity. EDA-A1 only binds EDAR, whereas EDA-A2 only binds to XEDAR. Mutations in EDA, EDAR and XEDAR have been associated with HED.
Headon, D.J. and P.A Overbeek (1999) Nat. Genet. 22:370.
Kumar, A. et al. (2000) J. Biol. Chem. 276:2668.
Monreal, A.W. et al. (1999) Nat. Genet. 22:366.
Schneider, P. et al. (2001) J. Biol. Chem. 276:18819.
Srivastava, A.K. et al. (1997) Proc. Natl. Acad. Sci. USA 94:13069.
Yan, M. et al. (2000) Science 290:523.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.