EDA2R/TNFRSF27/XEDAR Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, B/N
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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EDA2R/TNFRSF27/XEDAR Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human EDA2R/TNFRSF27/XEDAR
Met1-Glu136
Accession # Q9HAV5
Specificity
Detects human EDA2R/TNFRSF27/XEDAR in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
EDA2R
Purity
Immunogen affinity purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Blockade of Receptor-ligand Interaction
Publications
Read Publication using
AF1093 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for EDA2R/TNFRSF27/XEDAR Antibody

  • ectodysplasin A2 receptor
  • EDA2R
  • EDA-A2 receptor
  • EDAA2R
  • EDA-A2R
  • EDAA2Rtumor necrosis factor receptor superfamily member XEDAR
  • EDAR2
  • TNFRSF27
  • XEDAR
  • XEDARTNFRSF27tumor necrosis factor receptor superfamily member 27
  • X-linked ectodysplasin-A2 receptor

Background

X-linked ectodysplasin receptor (XEDAR) is a type III transmembrane that lacks an N-terminal signal peptide. It is an X-linked member of the TNF Receptor Superfamily (TNFRSF). Human XEDAR is a 297 amino acid (aa) protein with a 136 aa extracellular domain, a 21 aa transmembrane domain, and a 140 aa cytoplasmic domain. Within the TNFRSF, XEDAR shares the highest homologies with EDAR and TNFRSF19/TROY. EDA-A2 is the XEDAR ligand. XEDAR expression is principally found in embryonic hair follicles. XEDAR, EDAR, EDA-A1 and EDA-A2 have been associated with hypohidrotic ectodermal dysplasia (HED). HED is characterized by abnormalities in hair, teeth, and eccrine sweat gland morphogenesis. HED was initially found to associate with two gene loci, tabby and downless. Tabby was later identified as the gene for EDA and downless as the autosomal EDAR gene. EDA has two splice variants, EDA-A1 and EDA-A2 which differ by only two amino acids. Despite this minor difference, the EDA isoforms display strong receptor specificity. EDA-A1 only binds EDAR, whereas EDA-A2 only binds to XEDAR. Mutations in EDA, EDAR and XEDAR have been associated with HED.
  1. Headon, D.J. and P.A Overbeek (1999) Nat. Genet. 22:370.
  2. Kumar, A. et al. (2000) J. Biol. Chem. 276:2668.
  3. Monreal, A.W. et al. (1999) Nat. Genet. 22:366.
  4. Schneider, P. et al. (2001) J. Biol. Chem. 276:18819.
  5. Srivastava, A.K. et al. (1997) Proc. Natl. Acad. Sci. USA 94:13069.
  6. Yan, M. et al. (2000) Science 290:523.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for EDA2R/TNFRSF27/XEDAR Antibody (AF1093)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.


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Biotin BAF1093

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Bioinformatics

Gene Symbol EDA2R
Uniprot