E-Selectin/CD62E Antibody (HCD62E) [DyLight 650]

Product Discontinued

E-Selectin/CD62E Antibody (HCD62E) [DyLight 650] Summary

• Immunogen: The immunogen was the full length version of the protein: CD62E (HCD62E)
• Specificity: CD62E (HCD62E)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SELE
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for E-Selectin/CD62E Antibody (HCD62E) [DyLight 650]

• CD62 antigen-like family member E
• CD62E antigen
• CD62E
• ELAM
• ELAM1
• ELAM-1
• ELAM1E-selectin
• endothelial adhesion molecule 1
• Endothelial leukocyte adhesion molecule 1
• ESEL
• E-Selectin
• LECAM2
• leukocyte endothelial cell adhesion molecule 2
• Leukocyte-endothelial cell adhesion molecule 2
• SELE
• selectin E

Background

CD62E (also known as E-selectin, ELAM-1, and LECAM-1) is a 115 kD type I membrane protein and a member of the selectin family. CD62E is highly expressed on activated endothelial cells (IL-2, TNF- alpha, other cytokines can increase expression) and can also be expressed on endothelial cells in the skin, bone marrow and placenta. CD62E is involved in tethering and leucocyte rolling on activated endothelium at inflammatory sites and may also play a role in tumor metastasis and angiogenesis. CD62E binds to both Siayl Lewis X (CD15s) and PSGL-1 (CD162). The HCD62E antibody has been shown to recognize human CD62E and to be useful for flow cytometry.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for E-Selectin/CD62E Antibody (NB100-78061C). (Showing 1 - 1 of 1 FAQ).

1. Is #NB100-78061C a blocking antibody? Does it bind to the binding domain of the e-selectin protein and so will interfere with the binding to its ligand or does it not affect the binding of E-Selectin to its ligand?
   • Our E-selectin antibody with catalogue number NB100-78061 has currently only been validated for FLOW application and its blocking/neutralization ability has not been evaluated yet. However, because the immunogen used to generate this antibody was the full length version of CD62E protein, there is a good chance that it may have the ability of blocking E-selectin /CD62E protein.

Bioinformatics

• Gene Symbol: SELE