DYRK2 Antibody (599542) [Janelia Fluor® 669]

• Reactivity: Hu, Rt
• Applications: WB, IHC
• Clone: 599542
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

DYRK2 Antibody (599542) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human DYRK2
  aa 1-107
  Accession # NP_003574
• Specificity: Detects human and rat DYRK2 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: DYRK2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DYRK2 Antibody (599542) [Janelia Fluor® 669]

• dual specificity tyrosine-phosphorylation-regulated kinase 2
• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
• DYRK2
• EC 2.7.12
• EC 2.7.12.1
• FLJ21217
• FLJ21365

Background

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DYRK2