DYRK2 Products

Description

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.

Bioinformatics

Entrez	314862 Rat 69181 Mouse 8445 Human
Uniprot	AAH05809 Human NP_003574 Human NP_006473 Human Q92630 Human
Product By Gene ID	8445
Alternate Names	dual specificity tyrosine-phosphorylation-regulated kinase 2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 EC 2.7.12 EC 2.7.12.1 FLJ21217 FLJ21365

Research Areas for DYRK2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Protein Kinase