DUSP22 Antibody

Immunohistochemistry-Paraffin: DUSP22 Antibody [NLS6811] - Anti-DUSP22 antibody IHC of human acinar epithelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: DUSP22 Antibody [NLS6811] - Analysis of anti-DUSP22 / JSP 1 antibody with human colon, carcinoma.

Product Discontinued

DUSP22 Antibody Summary

• Immunogen: Synthetic 20 amino acid peptide from internal region of human DUSP22.
• Localization: Cytoplasmic
• Specificity: Human DUSP22. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ATAD3B (45%), TAF2 (35%).
• Predicted Species: Rabbit (90%), Equine (95%), Primate (95%), Monkey (95%), Bat (90%), Hamster (90%), Canine (90%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DUSP22
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1 - 7 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Elephant (100%), Marmoset (95%), Mouse (85%), Opossum (85%), Platypus (85%), Rat (80%), Bovine (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for DUSP22 Antibody

• dual specificity phosphatase 22
• dual specificity protein phosphatase 22
• EC 3.1.3.16
• EC 3.1.3.48
• FLJ35864
• homolog of mouse dual specificity phosphatase LMW-DSP2
• JKAP
• JNK-stimulating phosphatase 1
• JSP-1
• JSP1JNK-stimulatory phosphatase-1
• LMWDSP2
• LMW-DSP2
• Low molecular weight dual specificity phosphatase 2
• Mitogen-activated protein kinase phosphatase x
• MKP-x
• MKPXMAP kinase phosphatase x
• VHX

Background

MKPX, also known as JSP-1 for Jnk Stimulatory Phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated in a number of important physiological processes, including embryonic morphogenesis, cell survival and apoptosis. At least two mRNA transcripts have been reported. Jnk signaling has been linked to human disease conditions, such as tumor development, cardiac hypertrophy, ischemia/reperfusion injury, diabetes, hyperglycemia-induced apoptosis, and several neurodegenerative disorders.MKPX has been shown to be widely expressed with highest expression in heart, kidney, liver, lung, pancreas and placenta. ESTs have been isolated from a diverse set of human tissues libraries, especially blood and breast.Caution: The acronym MKPX also has been used to describe Dual Specificity Protein Phosphatase 7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DUSP22
• Entrez:
  • 56940(Human)