Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, Mycoplasma
Host: Mouse Monoclonal
Species: Hu, Mu, Bv, Eq, Pm, Pm, Rb
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
MKPX, also known as JSP-1 for Jnk Stimulatory Phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated in a number of important physiological processes, including embryonic morphogenesis, cell survival and apoptosis. At least two mRNA transcripts have been reported. Jnk signaling has been linked to human disease conditions, such as tumor development, cardiac hypertrophy, ischemia/reperfusion injury, diabetes, hyperglycemia-induced apoptosis, and several neurodegenerative disorders.MKPX has been shown to be widely expressed with highest expression in heart, kidney, liver, lung, pancreas and placenta. ESTs have been isolated from a diverse set of human tissues libraries, especially blood and breast.Caution: The acronym MKPX also has been used to describe Dual Specificity Protein Phosphatase 7.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
56940 |
| Alternate Names |
- dual specificity phosphatase 22
- dual specificity protein phosphatase 22
- EC 3.1.3.16
- EC 3.1.3.48
- FLJ35864
- homolog of mouse dual specificity phosphatase LMW-DSP2
- JKAP
- JNK-stimulating phosphatase 1
- JSP-1
- JSP1JNK-stimulatory phosphatase-1
- LMWDSP2
- LMW-DSP2
- Low molecular weight dual specificity phosphatase 2
- Mitogen-activated protein kinase phosphatase x
- MKP-x
- MKPXMAP kinase phosphatase x
- VHX
|
