DRAM Antibody

Images

 
Western Blot: DRAM Antibody [NB110-85526] - Western blot using NB110-85526 shows detection of a predominant band at ~33 kDa corresponding to DRAM (arrowhead) in K562 whole cell lysate. The predicted MW of DRAM is 26 ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-85526
    • Availability
      Product Discontinued

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DRAM Antibody Summary

Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human DRAM protein.
Specificity
This is directed against human DRAM protein. This reacts with DRAM from human, mouse and rat sources.
Clonality
Polyclonal
Host
Rabbit
Gene
DRAM1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • ELISA 1:10000-1:40000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
This affinity purified antibody has been tested for use in ELISA and western blotting. Expect a band at approx 33 kDa in size corresponding - DRAM by western blotting in the appropriate cell lysate or extract. K562 cell lysate can be used as positive control.

Reactivity Notes

This antibody is reactive to Human, Mouse, and Rat.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative
0.01% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for DRAM Antibody

  • Damage-regulated autophagy modulator
  • DNA damage-regulated autophagy modulator protein 1
  • DNA-damage regulated autophagy modulator 1
  • DRAMFLJ11259

Background

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Diseases for DRAM Antibody (NB110-85526)

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Bioinformatics

Gene Symbol DRAM1
Entrez
Uniprot