DRAK2 Antibody

Western Blot: DRAK2 Antibody [NB100-56695] - analysis of 30 ug of total cell lysate from Raji cells with anti-DRAK2 at 3 ug/ml dilution.

Product Discontinued

DRAK2 Antibody Summary

• Immunogen: This polyclonal antibody was raised against a peptide corresponding to amino acids 351 to 365 of human DRAK2 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: STK17B
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 2-4 ug/ml
• Control:

  Raji Whole Cell Lysate
  DRAK2 Overexpression Lysate

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: Protein G purified

Alternate Names for DRAK2 Antibody

• DAP kinase-related apoptosis-inducing protein kinase 2
• DRAK2
• DRAK2death-associated protein kinase-related 2
• EC 2.7.11
• EC 2.7.11.1
• serine/threonine kinase 17b (apoptosis-inducing)
• serine/threonine kinase 17b
• serine/threonine-protein kinase 17B
• STK17B

Background

Protein kinases play important roles in the signal transduction in response to a variety of external stimuli. Recently, several protein kinases have been identified that may also be involved in apoptotic process. Overexpression of a serine/threonine kinase, ZIP kinase can cause the morphological changes typical of apoptosis in NIH 3T3 cells. Sanjo et al, have identified two new protein kinases DRAK1 and DRAK2 (Death Receptor Associated Kinase 1 and 2). Both DRAKs and ZIP kinase share significant homology at the amino acid level. The kinase domains of both DRAKs, ZIP kinase are homologous to DAP (Death-associated protein) kinase, which is involved in the apoptotic signaling induced by interferon-g. Overexpression of DRAKs in NIH 3T3 cells lead to apoptosis. These transfection experiments suggest that C-terminal domain of DRAKs are important for induction of apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for DRAK2 Antibody (NB100-56695)(1)

Publication using NB100-56695

• Friedrich ML, Wen BG, Bain G et al. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005-11-01 [PMID: 16172133]

Bioinformatics

• Gene Symbol: STK17B