DPP6 Antibody - BSA Free

Immunohistochemistry-Paraffin: DPP6 Antibody [NBP3-14301] - Immunohistochemistry of formalin-fixed, paraffin-embedded human brain, neurons, after heat-induced antigen retrieval.

• Reactivity: Hu, Pm, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

DPP6 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 18 amino acid peptide near the center of human DPP6.
• Epitope: Internal
• Specificity: Human DPP6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DPP6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: .

Reactivity Notes

Expected reactivity based on percent sequence identity: Equine (89%), Bovine (83%)

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for DPP6 Antibody - BSA Free

• dipeptidyl aminopeptidase IV-related protein
• dipeptidyl aminopeptidase-like protein 6
• Dipeptidyl aminopeptidase-related protein
• Dipeptidyl peptidase 6
• Dipeptidyl peptidase IV-like protein
• dipeptidyl peptidase IV-related protein
• Dipeptidyl peptidase VI
• dipeptidylpeptidase 6
• dipeptidyl-peptidase 6
• dipeptidylpeptidase VI
• DPP VI
• DPP6
• DPPX
• DPPXFLJ55680
• MGC46605
• VF2

Background

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DPP6