DNASE1 Antibody

Western Blot: DNASE1 Antibody [H00001773-B01P] - Analysis of DNASE1 expression in transfected 293T cell line by DNASE1 polyclonal antibody. Lane 1: DNASE1 transfected lysate(31.02 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

DNASE1 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: DNASE1 (NP_005214, 1 a.a. - 282 a.a.) full-length human protein. MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
• Specificity: DNASE1 - deoxyribonuclease I,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: DNASE1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for DNASE1 Antibody

• deoxyribonuclease IFLJ38093
• deoxyribonuclease-1
• DKFZp686H0155
• DNase I
• DNase I, lysosomal
• DNL1FLJ44902
• Dornase alfa
• DRNI
• EC 3.1.21.1
• human urine deoxyribonuclease I

Background

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DNASE1
• Entrez:
  • 1773(Human)
• Uniprot:
  • NP_005214(Human)