DNAJB11 Antibody [DyLight 594]

Product Discontinued

DNAJB11 Antibody [DyLight 594] Summary

• Immunogen: DnaJ(Hsp40) homolog, subfamily B, member 11. (Uniprot# Q9UBS4)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DNAJB11
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DNAJB11 Antibody [DyLight 594]

• ABBP-2
• APOBEC1-binding protein 2
• DnaJ (Hsp40) homolog, subfamily B, member 11
• dnaJ homolog subfamily B member 11
• DnaJ protein homolog 9
• EDJABBP2
• ER-associated dnaJ protein 3
• ER-associated DNAJ
• ER-associated Hsp40 co-chaperone
• ERdj3DJ9
• ERJ3
• ERj3p
• hDj9
• hDj-9
• HEDJERj3
• Human DnaJ protein 9
• PRO1080
• PWP1-interacting protein 4
• UNQ537

Background

Members of the heat shock protein 40 (HSP 40) family of proteins all contain a highly conserved J domain that associates with HSP 70 and regulates the function of HSP 70 by activating its adenosine triphosphatase activity. ERdj3, an HSP 40 chaperone, is expressed in the ER lumen, where it interacts with BiP, a molecule involved in retrotranslocating proteins out of the ER. ERdj3 also associates with several other protein substrates, including unfolded light chains, a nonsecreted Ig light chain mutant and a VSV-G ts045 mutant. Shiga toxin (Stx) is a bacterial tool that enzymatically inactivates the 28S rRNA, inhibiting protein synthesis of infected cells. Stx also interacts with ERdj3 and Sec 61 to form a complex through which proteins are retrotranslocated to the cytoplasm. ERdj3 may play a role in the ER quality control system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DNAJB11