DNAJB11 Products

Description

Members of the heat shock protein 40 (HSP 40) family of proteins all contain a highly conserved J domain that associates with HSP 70 and regulates the function of HSP 70 by activating its adenosine triphosphatase activity. ERdj3, an HSP 40 chaperone, is expressed in the ER lumen, where it interacts with BiP, a molecule involved in retrotranslocating proteins out of the ER. ERdj3 also associates with several other protein substrates, including unfolded light chains, a nonsecreted Ig light chain mutant and a VSV-G ts045 mutant. Shiga toxin (Stx) is a bacterial tool that enzymatically inactivates the 28S rRNA, inhibiting protein synthesis of infected cells. Stx also interacts with ERdj3 and Sec 61 to form a complex through which proteins are retrotranslocated to the cytoplasm. ERdj3 may play a role in the ER quality control system.

Bioinformatics

Entrez	360734 Rat 51726 Human 67838 Mouse
Uniprot	AAH01144 Human NM_016306 Human NP_057390 Human Q9UBS4 Human
Product By Gene ID	51726
Alternate Names	ABBP-2 APOBEC1-binding protein 2 DnaJ (Hsp40) homolog, subfamily B, member 11 dnaJ homolog subfamily B member 11 DnaJ protein homolog 9 EDJABBP2 ER-associated dnaJ protein 3 ER-associated DNAJ ER-associated Hsp40 co-chaperone ERdj3DJ9 ERJ3 ERj3p HDJ9 hDj9 hDj-9 HEDJERj3 Human DnaJ protein 9 PRO1080 PWP1-interacting protein 4 UNQ537