DMPK Antibody (713931)

Images

 
Western blot shows lysates of human heart tissue. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human DMPK Monoclonal Antibody (Catalog # MAB6967) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
713931
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

DMPK Antibody (713931) Summary

Immunogen
E. coli-derived recombinant human DMPK
Glu393-Thr543
Accession # Q09013
Specificity
Detects human DMPK in direct ELISAs.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
DMPK
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DMPK Antibody (713931)

  • DM1
  • DM1PK
  • DMK
  • DMKEC 2.7.11.1
  • DM-kinase
  • DMmyotonin protein kinase A
  • DMPK
  • dystrophia myotonica-protein kinase
  • MDPK
  • MDPKDM protein kinase
  • MT-PK
  • MT-PKmyotonic dystrophy associated protein kinase
  • Myotonic dystrophy protein kinase
  • myotonin-protein kinase
  • thymopoietin homolog

Background

DMPK (dystrophia myotonica protein kinase), also called DMK, MDPK or MT-PK (myotonin protein kinase) is an 80 kDa cytoplasmic protein of the ser/thr kinase superfamily (EC 2.7.11.1). The 639 amino acid (aa) human DMPK includes a protein kinase domain (aa 81-349), an AGC kinase C-terminal domain (aa 350-425) and a coiled-coil negative regulatory domain that mediates dimerization (aa 467-546). Within the region used as an immunogen, human DMPK shares 72% and 73% aa sequence identity with mouse and rat DMPK, respectively. This region is included within 12 isoforms that range in size from 530-634 aa. The most prominent, muscle-specific isoform phosphorylates phospholamban and is critical for cardiac contractility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DMPK
Entrez
Uniprot