DMPK Antibody (713931) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB
• Clone: 713931
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

DMPK Antibody (713931) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human DMPK
  Glu393-Thr543
  Accession # Q09013
• Specificity: Detects human DMPK in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: DMPK
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DMPK Antibody (713931) [Janelia Fluor® 669]

• DM1
• DM1PK
• DMK
• DMKEC 2.7.11.1
• DM-kinase
• DMmyotonin protein kinase A
• DMPK
• dystrophia myotonica-protein kinase
• MDPK
• MDPKDM protein kinase
• MT-PK
• MT-PKmyotonic dystrophy associated protein kinase
• Myotonic dystrophy protein kinase
• myotonin-protein kinase
• thymopoietin homolog

Background

Dystrophia myotonica protein kinase is encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DMPK