Dkk-2 Antibody (C1) - BSA Free

Western Blot: Dkk-2 Antibody (C1) [NBP3-41437] - Sample: Recombinant Dkk-2, Human.

• Reactivity: Hu
• Applications: WB
• Clone: C1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Dkk-2 Antibody (C1) - BSA Free Summary

• Description: Novus Biologicals Mouse Dkk-2 Antibody (C1) - BSA Free (NBP3-41437) is a monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Immunized with recombinant Human Dkk-2 (Uniprot#: Q9UBU2; Ile38-Lys258 (Uniprot#: Q9UBU2)
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: DKK2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.01-2ug/mL

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.01M PBS, pH7.4, 50% glycerol
• Preservative: 0.05% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for Dkk-2 Antibody (C1) - BSA Free

• dickkopf (Xenopus laevis) homolog 2
• dickkopf 2
• dickkopf homolog 2 (Xenopus laevis)
• dickkopf related protein-2
• dickkopf-2
• dickkopf-related protein 2
• Dkk2
• Dkk-2
• hDkk-2

Background

Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DKK2