Dkk-2 Products

Antibodies
Dkk-2 Antibody
Dkk-2 Antibody
AF2435
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Dkk-2 Antibody
Dkk-2 Antibody
NB300-810
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Dkk-2 Antibody
Dkk-2 Antibody
NBP1-45520
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
Dkk-2 Overexpression Lysate ( ...
Dkk-2 Overexpression Lysate (Native)
NBP2-04343
Applications: WB
Proteins
Recombinant Human Dkk-2 Prote ...
Recombinant Human Dkk-2 Protein
NBP2-23000
Species: Hu
Applications: PAGE

Description

Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 27123
Alternate Names
  • dickkopf 2
  • Dkk-2
  • Dickkopf-2
  • DKK-2
  • dickkopf-related protein 2
  • dickkopf (Xenopus laevis) homolog 2
  • dickkopf-2
  • hDkk-2
  • dickkopf related protein-2
  • dickkopf homolog 2 (Xenopus laevis)

PTMs for Dkk-2

Learn more about PTMs related to Dkk-2.

Methylation
Phosphorylation
Demethylation
Glycosylation

Bioinformatics Tool for Dkk-2

Discover related pathways, diseases and genes to Dkk-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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