Dishevelled-1 Overexpression Lysate (Denatured)

• Reactivity: Hu
• Applications: WB

Dishevelled-1 Overexpression Lysate (Denatured) Summary

• Description: Plasmid: pCMV-DVL1 full-length
• Gene: DVL1

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for Dishevelled-1

• Type: Overexpression
• Protein State: Denatured

Notes

Quality control test: Transient overexpression cell lysate was tested with Anti-DVL1 antibody by Western Blots.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Dishevelled-1 Overexpression Lysate (Denatured)

• dishevelled 1 (homologous to Drosophila dsh)
• dishevelled, dsh homolog 1 (Drosophila)
• Dishevelled1
• Dishevelled-1
• DSH homolog 1
• Dsh
• DVL
• DVL1
• DVL1L1
• MGC54245
• segment polarity protein dishevelled homolog DVL-1

Background

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Transcript Variant: This variant (3) lacks an internal nt segment including several exons in the CDS, as compared to variant 1. The resulting isoform (c) has identical N- and C-termini but lacks an internal aa segment, as compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: DVL1
• Entrez:
  • 1855(Human)
  • 13542(Mouse)
  • 83721(Rat)