DISC1 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: 1.0 mg/ml

DISC1 Antibody Blocking Peptide Summary

• Description: A DISC1 antibody blocking peptide.
• Specificity: This peptide is specific for NB110-40775 only.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: DISC1

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB110-40775. For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: Peptide dissolved in dH2O. Contains no BSA.
• Preservative: No Preservative
• Concentration: 1.0 mg/ml

Alternate Names for DISC1 Antibody Blocking Peptide

• C1orf136
• DISC1
• disrupted in schizophrenia 1 protein
• disrupted in schizophrenia 1
• FLJ13381
• FLJ21640
• FLJ25311
• FLJ41105
• KIAA0457
• SCZD9

Background

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: DISC1