DIO1 Antibody [HRP]

Product Discontinued

DIO1 Antibody [HRP] Summary

• Immunogen: deiodinase, iodothyronine, type I. (Uniprot# P49895)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DIO1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for DIO1 Antibody [HRP]

• 5DI
• deiodinase, iodothyronine, type I
• DIOI
• EC 1.97.1
• EC 1.97.1.10
• ITDI1
• MGC130050
• thyroxine deiodinase type I (selenoprotein)
• TXDI1MGC130051
• Type 1 DI
• type I iodothyronine deiodinase
• Type-I 5'-deiodinase

Background

Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkappaB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DIO1