DGK-delta Antibody (625423) [PerCP]

• Reactivity: Hu
• Applications: WB
• Clone: 625423
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

DGK-delta Antibody (625423) [PerCP] Summary

• Immunogen: E. coli-derived recombinant human DGF-δ
  Ile570-Thr717
  Accession # Q16760
• Specificity: Detects human DGF-δ in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: DGKD
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for DGK-delta Antibody (625423) [PerCP]

• 130 kDa diacylglycerol kinase
• DAG kinase delta
• DGKD
• dgkd-2
• DGKdelta
• DGK-delta
• diacylglycerol kinase delta
• diacylglycerol kinase, delta (130kD)
• diacylglycerol kinase, delta 130kDa
• Diglyceride kinase delta
• FLJ26930
• KIAA0145EC 2.7.1.107

Background

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-episilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DGKD