DGK-delta Products

Description

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DAG) to produce phosphatidic acid. DAG and phosphatidic acid are lipids that act as second messengers in signaling cascades. DGK-alpha influences cell activation and secretion of lethal exosomes, which in turn control cell death. DGK-beta is abundant in restricted brain regions such as the caudate putamen and olfactory tubercle. DGK-gamma encodes full-length and truncated transcripts that are present in a range of human tissues, with greatest expression observed in retina. DGK-delta is most abundant in skeletal muscle. DGK-episilon shows specificity for arachidonylcontaining diacylglycerol and is expressed predominantly in testis. DGK-theta is most abundant in the cerebellum and hippocampus. DGK-iota is present in brain and retina as a predominant transcript of more than 12 kb, including a long 3-prime untranslated region, with additional low abundance transcripts of 9.5 and 7.5 kb. DGK-eta is closely related to DGK-delta. DGK-zeta is most abundant in brain and muscle. DGKs have structural motifs that play regulatory roles, and these motifs form the basis for dividing the DGKs into five subtypes.

Bioinformatics

Entrez	8527 Human
Uniprot	Q16760 Human
Product By Gene ID	8527
Alternate Names	130 kDa diacylglycerol kinase DAG kinase delta dgkd-2 DGKdelta DGK-delta diacylglycerol kinase delta diacylglycerol kinase, delta (130kD) diacylglycerol kinase, delta 130kDa Diglyceride kinase delta FLJ26930 KIAA0145EC 2.7.1.107

Research Areas for DGK-delta

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism