Desmoglein-3 Antibody (5G11) [HRP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P, IP
Clone
5G11
Clonality
Monoclonal
Host
Mouse

Desmoglein-3 Antibody (5G11) [HRP] Summary

Immunogen
Human Desmoglein 3 recombinant protein [UniProt# P32926]
Localization
Cell membrane; Single-pass type I membrane protein. Cell junction > desmosome
Specificity
This antibody reacts with Desmoglein 3. Does not cross-react with Desmoglein 1 or Desmoglein 2.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DSG3
Purity
Protein G purified
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Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
HRP
Format
HRP
Buffer
PBS
Preservative
No Preservative
Purity
Protein G purified

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:200
  • Immunohistochemistry-Paraffin 1:200
  • Immunoprecipitation 1:10-1:500
Application Notes
This Desmoglein 3 (5G11) antibody is useful for Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot.
Readout System

Reactivity Notes

Human.

Alternate Names for Desmoglein-3 Antibody (5G11) [HRP]

  • Cadherin family member 6
  • CDHF6
  • CDHF6130-kD pemphigus vulgaris antigen
  • desmoglein 3 (pemphigus vulgaris antigen)
  • desmoglein 3
  • Desmoglein3
  • Desmoglein-3
  • DKFZp686P23184,130 kDa pemphigus vulgaris antigen
  • DSG3
  • pemphigus vulgaris antigen
  • PVA

Background

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Desmoglein-3 Antibody (NB100-1643H) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-1643APC
Biotin Labeled NB100-1643B
DyLight 350 Labeled NB100-1643UV
DyLight 405 Labeled NB100-1643V
DyLight 405LS Labeled NB100-1643V3
DyLight 488 Labeled NB100-1643G
DyLight 550 Labeled NB100-1643R
DyLight 650 Labeled NB100-1643C
DyLight 680 Labeled NB100-1643FR
DyLight 755 Labeled NB100-1643IR
FITC Labeled NB100-1643F
PE Labeled NB100-1643PE
PerCP Labeled NB100-1643PCP

Additional Desmoglein-3 Antibody (5G11) [HRP] Products

Desmoglein-3 NB100-1643H

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Blogs on Desmoglein-3.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol DSG3
Entrez

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