Desmoglein-3 Antibody (5G11) [DyLight 650]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IHC, IHC-P
Clone
5G11
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

Desmoglein-3 Antibody (5G11) [DyLight 650] Summary

Immunogen
Human Desmoglein 3 recombinant protein [UniProt# P32926]
Localization
Cell membrane; Single-pass type I membrane protein. Cell junction > desmosome
Specificity
This antibody reacts with Desmoglein 3. Does not cross-react with Desmoglein 1 or Desmoglein 2.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DSG3
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Desmoglein 3 (5G11) antibody is useful for Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Desmoglein-3 Antibody (5G11) [DyLight 650]

  • Cadherin family member 6
  • CDHF6
  • CDHF6130-kD pemphigus vulgaris antigen
  • desmoglein 3 (pemphigus vulgaris antigen)
  • desmoglein 3
  • Desmoglein3
  • Desmoglein-3
  • DKFZp686P23184,130 kDa pemphigus vulgaris antigen
  • DSG3
  • pemphigus vulgaris antigen
  • PVA

Background

Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Desmoglein-3 Antibody (NB100-1643C) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-1643APC
Biotin Labeled NB100-1643B
DyLight 350 Labeled NB100-1643UV
DyLight 405 Labeled NB100-1643V
DyLight 488 Labeled NB100-1643G
DyLight 550 Labeled NB100-1643R
DyLight 680 Labeled NB100-1643FR
DyLight 755 Labeled NB100-1643IR
FITC Labeled NB100-1643F
HRP Labeled NB100-1643H
PE Labeled NB100-1643PE

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Bioinformatics Tool for Desmoglein-3 Antibody (NB100-1643C)

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Blogs on Desmoglein-3.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

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Bioinformatics

Gene Symbol DSG3
Entrez