Desmocollin-2 Antibody

Images

 
Western Blot: Desmocollin-2 Antibody [NBP1-32961] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE, antibody diluted at 1:500.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-32961] - Paraffin-embedded OVCAR3 xenograft, using antibody at 1:500 dilution.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Desmocollin-2 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Desmocollin 2. The exact sequence is proprietary.
Localization
Cell membrane, Cell junction, desmosome
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DSC2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Desmocollin-2 Antibody

  • ARVD11
  • Cadherin family member 2
  • CDHF2
  • CDHF2DGII/III
  • desmocollin 2
  • Desmocollin2
  • Desmocollin-2
  • Desmocollin-3
  • Desmosomal glycoprotein II
  • desmosomal glycoprotein II/III
  • Desmosomal glycoprotein III
  • DG2
  • DSC2
  • DSC3DKFZp686I11137

Background

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DSC2
Entrez