DEPTOR/DEPDC6 Antibody [DyLight 488]

• Reactivity: Hu, Mu, Rt, Bv
• Applications: WB, ICC/IF, IHC, KO
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 488

DEPTOR/DEPDC6 Antibody [DyLight 488] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: A genomic peptide made to an internal region of the human DEPTOR protein (within residues 10-200). [Swiss-Prot: Q8TB45]
• Localization: Intracellular.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DEPTOR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockout Validated
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-49674. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 31176743).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for DEPTOR/DEPDC6 Antibody [DyLight 488]

• DEP domain containing 6
• DEP domain containing mTOR interacting protein
• DEP domain containing MTOR-interacting protein
• DEP domain-containing mTOR-interacting protein
• DEP domain-containing protein 6
• DEP.6
• DEPDC6
• DEPDC6FLJ12341
• DEPTOR
• DKFZp564B1778
• FLJ12428
• FLJ13854

Background

Deptor interacts with the mammalian target of rapamycin (mTOR), inhibiting kinase activities and ultimately negatively regulating the downstream mTOR pathways. Because of its critical role in signaling, changes in expression levels of Deptor can lead to hyperplasia, apoptosis, and several cancers. Deptor seems to lead to cytokine cascades that are important in endometriosis and the induction of labor. Through mTOR interactions, Deptor is implicated in pathways for cell growth and differentiation, as well as cell-cycle prolongation or termination.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DEPTOR