Daxx Antibody

Product Discontinued

Daxx Antibody Summary

• Immunogen: Synthetic peptide from human Daxx.
• Specificity: Amino acids 261-274 of human DAXX protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DAXX
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:7000-1:45000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:200-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
• Preservative: 0.01% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Daxx Antibody

• BING2
• CENP-C binding protein
• DAP6
• DAP6MGC126245
• Daxx
• death domain-associated protein 6
• death-associated protein 6
• death-domain associated protein
• EAP1
• ETS1-associated protein 1
• Fas death domain-associated protein
• Fas-binding protein
• hDaxx
• MGC126246

Background

DAXX, the Death domain associated protein 6 (also named Fas death domain associated protein, ETS1-associated protein 1 or EAP1), functions in part as a transcriptional co-repressor through its interaction with a number of nuclear, DNA-associated proteins, such as histone deacetylase II, core histones H2A, H2B, H3 and H4, and Dek, a chromatin- associated protein reported to change the topology of DNA in chromatin in vitro (1). DAXX also interacts with p73, and is involved in the regulation of the cell cycle and apoptosis through transcriptional regulation of p53 and possibly its family members (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Daxx Antibody (NBP1-03157)(1)

Publication using NBP1-03157

• Weisbrod AB, Zhang L, Jain M et al. Altered PTEN, ATRX, CHGA, CHGB, and TP53 Expression Are Associated with Aggressive VHL-Associated Pancreatic Neuroendocrine Tumors. Horm Cancer 2013-01-30 [PMID: 23361940] (IHC-P, Human)

Bioinformatics

• Gene Symbol: DAXX
• Entrez:
  • 1616(Human)
  • 13163(Mouse)
  • 140926(Rat)
• Uniprot:
  • Q9UER7()