Daxx Products

Antibodies
Daxx Antibody
Daxx Antibody
NB100-56136
Species: Hu, Mu, Rt, Bv, Ca, Pm
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Daxx Antibody
Daxx Antibody
AF4548
Species: Hu
Applications: WB
Host: Goat Polyclonal
Daxx Antibody (7A11)
Daxx Antibody (7A11)
NBP1-47453
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF
Host: Mouse Monoclonal
Lysates
Daxx Overexpression Lysate (N ...
Daxx Overexpression Lysate (Native)
NBL1-09722
Applications: WB
Daxx Overexpression Lysate (N ...
Daxx Overexpression Lysate (Native)
NBP2-09623
Applications: WB
Daxx Overexpression Lysate (N ...
Daxx Overexpression Lysate (Native)
NBP2-09622
Applications: WB
Proteins
Recombinant Human Daxx Protei ...
Recombinant Human Daxx Protein
H00001616-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Daxx Protei ...
Recombinant Human Daxx Protein
H00001616-P01
Species: Hu
Applications: WB, ELISA, PA
Daxx Recombinant Protein Anti ...
Daxx Recombinant Protein Antigen
NBP1-85309PEP
Species: Hu
Applications: AC
RNAi
Daxx RNAi
Daxx RNAi
H00001616-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Daxx (death-domain-associated protein) was originally identified as a cytoplasmic protein that binds to the death domain of the transmembrane death receptor Fas. It is now that known that the a large porportion of Daxx molecules are nuclear and associate with the promyelocytic leukaemia nuclear body (PML-NB) and other subnuclear domains (reviewed in Salomoni and Khelifi). The promyelocytic leukemia protein Pml is an essential component of the PML-NB. Data suggests that certain stimuli including Fas stimulation, causes Daxx to be translocated from the nucleus to the cytoplasm. Daxx is ubiquitously expressed, and particularly high levels of Daxx have been reported in the thymus and testes. At the cellular level Daxx may be found in cytoplasm and within heterochromatic regions of the nucleus. Daxx has been reported to interact and co-localize with Pml in the nucleus of tumor cell lines and primary cells. Pml is necessary for Fas-induced cell death and Daxx pro-apoptotic functions. Daxx is thought to have both pro- and anti-apoptotic functions depending on the stimulus and the cell type. Daxx pro-apoptotic functions appear to occur in both the cytoplasm and nucleus. Although the mechanisms remain to be fully elucidated, research indicates that Daxx plays a role in the pathology of human diseases including cancer and neurodegerative disorders. Human Daxx is a 740 amino acid protein (GenBank no. gi/62898369).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1616
Alternate Names
  • Daxx
  • ETS1-associated protein 1
  • Fas-binding protein
  • EAP1
  • death domain-associated protein 6
  • BING2
  • CENP-C binding protein
  • Fas death domain-associated protein
  • MGC126246
  • death-associated protein 6
  • DAP6MGC126245
  • hDaxx
  • death-domain associated protein

Research Areas for Daxx

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for Daxx

Discover related pathways, diseases and genes to Daxx. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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