DACT3/Dapper 3 Antibody

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Western Blot: DACT3/Dapper 3 Antibody [NBP1-76340] - Rat brain tissue lysate with Dact3 antibody at 1 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

DACT3/Dapper 3 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Dact3. The immunogen is located within amino acids 370 - 420 of Dact3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DACT3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
Application Notes
Dact3 antibody can be used for detection of Dact3 by Western blot at 1 - 2 mg/ml.
Control Peptide
DACT3/Dapper 3 Peptide (NBP1-76340PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DACT3/Dapper 3 Antibody

  • Antagonist of beta-catenin Dapper homolog 3
  • arginine rich region 1
  • Arginine-rich region 1 protein
  • DACT3
  • Dapper 3
  • dapper homolog 3
  • dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
  • MGC15476
  • RRR1

Background

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DACT3
Entrez
Uniprot