Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL Antibody (464702)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 464702
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL Antibody (464702) Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL
  Met1-Asp475
  Accession # Q96KP4
• Specificity: Detects human Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human CNDP1 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CNDP2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL Antibody (464702)

• CN2
• CN2cytosolic non-specific dipeptidase
• CNDP dipeptidase 2 (metallopeptidase M20 family)
• CNDP dipeptidase 2
• CNDP2
• CPGL
• CPGLcytosolic nonspecific dipeptidase
• FLJ10830
• HsT2298
• PEPA
• PEPAEC 3.4.13.18
• Peptidase AGlutamate carboxypeptidase-like protein 1

Background

The human CNDP2 gene encodes cytosol non-specific dipeptidase, a member of the M20 family of metalloproteases (1, 2). Also known as glutamate carboxypeptidase-like protein 1 (CPGL), tissue carnosinase or peptidase A, CNDP2 is ubiquitously expressed throughout human tissues. Unlike CNDP1, CNDP2 has broad substrate specificity for dipeptides with free amino and carboxyl groups. The amino acid sequence of human CNDP2 is 90% and 84% identical to that of dog/mouse/rat and chicken, respectively.

1. Teufel, M. et al. (2003) J. Biol. Chem. 278:6521.
2. Woessner, J. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, A.J. et al.) pp.1020, Academic Press, San Diego.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cytosol Nonspecific Dipeptidase (CNDP2)/CPGL Antibody (MAB3560)(1)

Publication using MAB3560

• Nicholas T. Seyfried, Yair M. Gozal, Laura E. Donovan, Jeremy H. Herskowitz, Eric B. Dammer, Qiangwei Xia et al. Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards Journal of Proteome Research 2012-05-04 [PMID: 22416763]

Bioinformatics

• Gene Symbol: CNDP2
• Uniprot:
  • Q96KP4()