Cytokeratin 10/13 Antibody (DE-K13)

Immunohistochemistry: Cytokeratin 10/13 Antibody (DE-K13) [NBP1-22538] - IHC analysis of Cytokeratin 10/13 formalin-fixed paraffin embedded human tonsil using NBP1-22538.

Product Discontinued

Cytokeratin 10/13 Antibody (DE-K13) Summary

• Immunogen: BALB/C mice were immunized with detergent insoluble extract of human epidermis.
• Localization: Cytoplasmic
• Specificity: This antibody recognizes keratin polypeptides of 53 and 56.5KD. It stains suprabasal cells in the epidermis, thymic Hassal's bodies, urothelium and non-cornifying stratified epithelia of vagina, ectocervix, tongue and esophagus. This does not stain intraepithelial neoplasm and invasive squamous cell carcinoma.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: KRT10
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tissue culture supernatant
• Preservative: 0.09% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for Cytokeratin 10/13 Antibody (DE-K13)

• BCIE
• BIE
• CK10
• CK-10
• cytokeratin 10
• Cytokeratin-10
• EHK
• K10keratosis palmaris et plantaris
• keratin 10
• keratin, type I cytoskeletal 10
• keratin-10
• KPP

Background

Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non-keratinizing cells (ie. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KRT10