Cytochrome P450 2D6 Antibody

Images

 
Western Blot: Cytochrome P450 2D6 Antibody [H00001565-B01P] - Analysis of CYP2D6 expression in human liver.
Western Blot: Cytochrome P450 2D6 Antibody [H00001565-B01P] - Analysis of CYP2D6 expression in transfected 293T cell line by CYP2D6 polyclonal antibody. Lane 1: CYP2D6 transfected lysate(54.67 KDa). Lane 2: ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Cytochrome P450 2D6 Antibody Summary

Immunogen
CYP2D6 (AAH75023.1, 1 a.a. - 497 a.a.) full-length human protein. MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
Specificity
CYP2D6 - cytochrome P450, family 2, subfamily D, polypeptide 6,
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
CYP2D6
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cytochrome P450 2D6 Antibody

  • CPD6P450DB1
  • CYP2D
  • CYP2D7AP
  • CYP2D7BP
  • CYP2D7P2
  • CYP2D8P2
  • CYP2DL1
  • CYPIID6
  • cytochrome P450 2D6
  • cytochrome P450, family 2, subfamily D, polypeptide 6
  • cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
  • cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
  • cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising)
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc.
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising)
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)
  • Cytochrome P450-DB1
  • Debrisoquine 4-hydroxylase
  • EC 1.14.14.1
  • flavoprotein-linked monooxygenase
  • -metabolizing)-like 1
  • MGC120389
  • MGC120390
  • microsomal monooxygenase
  • P450C2D
  • P450-DB1
  • polypeptide 6
  • polypeptide 7 pseudogene 2
  • polypeptide 8 pseudogene 2
  • xenobiotic monooxygenase

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CYP2D6
Entrez
Uniprot