Cytochrome P450 2A6 Antibody

Images

 
Western Blot: Cytochrome P450 2A6 Antibody [H00001548-B01P] - Analysis of CYP2A6 expression in human liver.
Western Blot: Cytochrome P450 2A6 Antibody [H00001548-B01P] - Analysis of CYP2A6 expression in transfected 293T cell line by CYP2A6 polyclonal antibody. Lane 1: CYP2A6 transfected lysate(54.34 KDa). Lane 2: ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Cytochrome P450 2A6 Antibody Summary

Immunogen
CYP2A6 (AAH96255.1, 1 a.a. - 494 a.a.) full-length human protein. MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR
Specificity
Reacts with cytochrome P450, family 2, subfamily A, polypeptide 6.
Isotype
IgG
Clonality
Polyclonal
Host
Mouse
Gene
CYP2A6
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This antibody is reactive against tissue and transfected lysate in WB and as a detection antibody in ELISA.
Publications
Read Publication using H00001548-B01P.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cytochrome P450 2A6 Antibody

  • Coumarin 7-hydroxylase
  • CPA6
  • CYP2A3P450C2A
  • CYP2AEC 1.14.14.1
  • CYPIIA6
  • cytochrome P450 2A6
  • Cytochrome P450 IIA3
  • Cytochrome P450(I)
  • cytochrome P450, family 2, subfamily A, polypeptide 6
  • cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
  • flavoprotein-linked monooxygenase
  • P450PB
  • xenobiotic monooxygenase

Background

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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H00001548-B01P
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Applications: WB

Publications for Cytochrome P450 2A6 Antibody (H00001548-B01P)(1)

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Bioinformatics

Gene Symbol CYP2A6
Entrez
Uniprot