Cyclin A1 Antibody (722407) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 722407
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Cyclin A1 Antibody (722407) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Cyclin A1
  Lys51-Arg220
  Accession # P78396
• Specificity: Detects human Cyclin A1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Cyclin A2, B1, B2, C, D1, D2, D3, E1, E2, or recombinant mouse Cyclin A1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cyclin A1 Antibody (722407) [Alexa Fluor® 750]

• CCNA1
• Cyclin A1
• cyclin-A1

Background

Cyclin A1, also known as CCNA1, is a 64 kDa protein that associates with the kinase Cdk2. This complex phosphorylates multiple substrates involved in regulation of cell cycle progression, apoptosis, double strand DNA break repair, and mRNA splicing. Cyclin A1 activity promotes G2/M phase transition in spermatocyte meiosis and G1/S transition in somatic cells. Cyclin A1 is upregulated in myeloid leukemia, testicular germ cell tumors, and several carcinomas. It contains two cyclin box folds (aa 243-318 and 340-427). Over aa 51-220, human Cyclin A1 shares approximately 75% aa identity with mouse and rat Cyclin A1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.