CTR2 Antibody [FITC]

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: FITC

CTR2 Antibody [FITC] Summary

• Immunogen: Synthetic peptide made to an internal portion of human CTR2 (within residues 50-100). [Swiss-Prot# O15432]
• Localization: Membrane; Multi-pass membrane protein (probable)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SLC31A2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This CTR2 antibody is useful for Western blot, where a band is seen at ~71 kDa. The theoretical molecular weight of CTR2 is 15 kDa. The difference between the expected size and the observed size in Western blot is believed to be due to a multimeric form of CTR2 (Bertinato et al). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 71 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for CTR2 Antibody [FITC]

• Copper transporter 2
• COPT2SLC13A2
• CTR2Solute carrier family 31 member 2
• hCTR2probable low affinity copper uptake protein 2
• solute carrier family 31 (copper transporters), member 2

Background

CTR2 (copper transporter 2) belongs to copper transporter (Ctr) (TC 1.A.56) family/SLC31A subfamily and it is a second Cu permease enzyme with high similarity in sequence as well as in overall organization to CTR1 i.e. 3 putative transmembrane domains with an intramembranous MX3M motif, however, it does not have an extended N-terminal domain. CTR2 localizes to intracellular compartments, most notably the endosome or lysosome and it mediates Cu transport into the cytoplasm based on measures of elevated Cu accumulation or metal responsive reporter activation in cells in which CTR2 levels have been altered.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for CTR2 Antibody (NBP1-05199F). (Showing 1 - 1 of 1 FAQ).

1. I have searched your website to find ctr2 antibody for my rat experiment(mainly about IHC &WB), however, I found most ctr2 antibody used for mouse and human not for rat.Could you help me to check the information on ctr2 antibody ?Thanks a lot!
   • We have two antibodies to CTR2 - NBP1-05199 which is validated for Western blotting using samples from human and mouse, and NBP1-85512 which is validated for IHC-P using human samples. Human and mouse CTR2 share a 77% sequence homology, however I am unable to align either of these sequence with that of the rat protein, since the rat sequence is not available on UniProt. If you have the rat sequence I would be happy to perform the alignment for you, email technical@novusbio.com. If you wish to try either of these antibodies in an untested species or application I can strongly recommend our Innovators Reward Program. To participate you simply complete an online review with an image, detailing the positive or negative results of your study, and in return you receive a discount voucher for 100% of the purchase price of the reviewed product. This allows us to gain more information on our products, and enables you to save money.

Bioinformatics

• Gene Symbol: SLC31A2