CtBP1 Antibody

Product Discontinued

CtBP1 Antibody Summary

• Immunogen: Bacterially expressed full-length human CtBP1 (NM_001012614.1).
• Specificity: The polyclonal antibody reacts with CtBP1, a 49 kDa transcriptional corepressor, that plays a critical role in regulating gene expression.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CTBP1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1 ug/ml
  • Immunoprecipitation 1:50
  • Western Blot 1:1000
• Application Notes: Western Blotting - Reducing conditions. Immunocytochemistry - Staining technique: acetone / methanol fixation
• Theoretical MW: 49 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• Preservative: 15mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Affinity purified

Alternate Names for CtBP1 Antibody

• BARS
• brefeldin A-ribosylated substrate
• CTBP
• CtBP1
• C-terminal binding protein 1
• C-terminal-binding protein 1
• EC 1.1.1
• EC 1.1.1.-
• EC 1.1.1.158
• MGC104684

Background

C-terminal binding protein 1 / brefeldin A (BFA)-dependent ADP-ribosylation substrate (CtBP1/BARS) is a highly conserved transcriptional corepressor, that plays a critical role in regulating gene expression patterns throughout development and in oncogenesis. CtBP regulates target gene transcription, in part, via recruitment of histone deacetylases involved in gene silencing and may act to coordonate histone modifications that regulate gene expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CtBP1 Antibody (NBP1-44886)(1)

Publication using NBP1-44886

• Huang Y, Kesselman D, Kizub D et al. Phospho-deltaNp63alpha/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. Cell Cycle 2013-02-15 [PMID: 23343772] (WB, Human)

Bioinformatics

• Gene Symbol: CTBP1
• Entrez:
  • 1487(Human)
  • 13016(Mouse)
• Uniprot:
  • Q13363()