CSRP2 Antibody [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 700

CSRP2 Antibody [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human CSRP2
  Met1-Gln193
  Accession # Q16527
• Specificity: Detects human CSRP2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CSRP2 Antibody [Alexa Fluor® 700]

• CRP2
• CRP2LIM domain only protein 5
• CSRP2
• cysteine and glycine-rich protein 2
• Cysteine-rich protein 2
• LMO5LMO-5
• SmLIM
• SmLIMLIM domain only 5, smooth muscle
• Smooth muscle cell LIM protein

Background

CSRP2 (Cysteine‑rich protein 2/CRP2; also Cysteine and Glycine‑rich protein 2, LMO‑5 and SmLIM) is a 21‑22 kDa member of the CRP family of LIM domain‑containing proteins. It is expressed in arterial smooth muscle, hepatic stellate cells and fibroblasts. CSRP2 is up‑regulated by TGF‑ beta and down‑regulated by PDGF, and appears to interact with PIAS1 and CRP2‑BP, thus promoting STAT signaling. It also binds to SRF and GATA4 to initiate smooth muscle differentiation. Human CSRP2 is 193 amino acids (aa) in length and contains two 50 aa LIM (for lin11/isl1/mec3) domains that contain two zinc‑finger motifs (aa 10‑61 and 119‑170), an NLS between aa 64‑69, and a Gly‑rich C‑terminus (aa 176‑187). Full‑length human CSRP2 shares 79% aa identity with human CSRP1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.