CRELD2 Antibody [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

CRELD2 Antibody [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CRELD2 α Isoform
  Ala21-Leu353
  Accession # AAH50675
• Specificity: Detects human CRELD2 alpha isoform in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross‑reactivity with recombinant mouse (rm) CRELD2 is observed and less than 1% cross-reactivity with recomb
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CRELD2 Antibody [Alexa Fluor® 647]

• CRELD2
• cysteine-rich with EGF-like domain protein 2
• cysteine-rich with EGF-like domains 2
• DKFZp667O055
• MGC11256

Background

CRELD2 is an ubiquitously expressed protein that is a second member of the CRELD family of matricellular proteins. Human CRELD2 alpha isoform is synthesized as a 353 amino acid residue precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE), and EGF-like repeats. Multiple isoforms, including the beta isoform with a 27 aa substitution for the C-terminal 96 residues of the alpha isoform, and another isoform with a 32 residue deletion between residues 258 and 289, have been reported. Human CRELD2 has been shown to interact with the alpha 4 subunit of the nicotinic acetylcholine receptor and function as a specific regulator of receptor expression. Human CRELD2 shares 76% and 77% amino acid sequence homology with mouse and rat CRELD 2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.