CRACC/SLAMF7 Antibody (235614) [Allophycocyanin]

Human peripheral blood mononuclear cells (PBMCs) gated on CD3-cells were stained with Mouse Anti-Human NCAM-1/CD56 PE-conjugated Monoclonal Antibody (Catalog # FAB2408P) and either (A) Mouse Anti-Human CRACC/SLAMF7 APC-conjugated Monoclonal Antibody (Catalog # FAB1906A) or (B) Mouse IgG2AAllophycocyanin Isotype Control (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 235614
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

CRACC/SLAMF7 Antibody (235614) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CRACC/SLAMF7
  Lys27-Ser225
  Accession # Q9NQ25
• Specificity: Detects human CRACC/SLAMF7 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human NTB-AR is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLAMF7
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CRACC/SLAMF7 Antibody (235614) [Allophycocyanin]

• 19A
• CD2 subset 1
• CD2-like receptor activating cytotoxic cells
• CD319 antigen
• CD319
• CRACC
• CRACCCD2-like receptor-activating cytotoxic cells
• CS119A24 protein
• Membrane protein FOAP-12
• novel LY9 (lymphocyte antigen 9) like protein
• Novel Ly9
• Protein 19A
• SLAM family member 7
• SLAMF7

Background

CRACC, also known as CSI (CD2 subset I), is a type I transmembrane protein belonging to the CD2 subset of the Ig superfamily. CRACC is expressed on most NK cells and subsets of CD8⁺ cells, CD4⁺ cells and B cells. CRACC may play a role in the activation and effector function of T cells and NK cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CRACC/SLAMF7 Antibody (FAB1906A)(1)

Publication using FAB1906A

• K Lisenko, SO Schönland, A Jauch, M Andrulis, C Röcken, AD Ho, H Goldschmid, U Hegenbart, M Hundemer Flow cytometry-based characterization of underlying clonal B and plasma cells in patients with light chain amyloidosis Cancer Med, 2016-04-25;0(0):. 2016-04-25 [PMID: 27109862] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: SLAMF7
• Uniprot:
  • Q9NQ25()