CD84/SLAMF5 Antibody (273508)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
273508
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

CD84/SLAMF5 Antibody (273508) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD84/SLAMF5
Lys22-Arg220
Accession # Q9UIB8.1
Specificity
Detects human CD84/SLAMF5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse CD84 is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CD84
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB1855 in the following applications:

  • 1 publication
  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD84/SLAMF5 Antibody (273508)

  • CD84 antigen (leukocyte antigen)
  • CD84 antigen
  • CD84 molecule
  • CD84
  • Cell surface antigen MAX.3
  • DKFZp781E2378
  • hCD84
  • hly9-beta
  • leucocyte differentiation antigen CD84
  • leukocyte antigen CD84
  • Leukocyte differentiation antigen CD84
  • Ly-9B
  • mCD84
  • Signaling lymphocytic activation molecule 5
  • SLAM family member 5
  • SLAMF5
  • SLAMF5LY9B

Background

The CD2 family receptors are type I transmembrane glycosylated proteins belonging to the immunoglobulin (Ig) superfamily. They are characterized by an extracellular region containing an N-terminal variable (V) Ig domain lacking disulfide bonds and a truncated Ig constant 2 (C2) domain with two disulfide bonds (1). CD84, also known as Ly-9B, is a member of the CD150/SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family and is designated SLAMF5 (2). The SLAM family, comprising at least nine members, is defined by the presence of at least two immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region. The ITSM motifs interact with the SH2 (Src homology 2) domain of cytoplasmic adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS/FliI-activated transcript 2) to transduce SLAM family receptor-mediated signals (2). SLAM family receptors are thought to mediate cell adhesion in the immune synapse between T cells and antigen-presenting cells to modulate immune responses. Human CD84 cDNA encodes a 328 amino acid residue (aa) precursor protein with a 21 aa signal peptide and a 199 aa extracelllular domain (3). It is expressed on B and T cells, monocytes and platelets (3, 4). CD84 is a self-ligand. The homotypic CD84-CD84 interaction requires only the first N-terminal Ig V domai (4). In T cells, CD84 has been found to act as a co-stimulatory molecule, enhancing anti-CD3 induced IFN-gamma production in lymphocytes and increasing anti-CD3 induced proliferation in PHA T cells blasts (4, 5). In B cells, CD84 is differentially expressed, with the CD84hi B cells representing a subset of memory B cells (6). While ligation of CD84 in the memory B cells leads to the recruitment of SAP and EAT-2 the exact role CD84 has in memory B cell functions remains to be determined.The exact role played by CD84 in B cells functions remains to be determined. Human and mouse CD84 share approximately 57% aa sequence identity.

  1. Tangye, S.G. et al. (2000) Semin. Immunol. 12:149. 
  2. Engel, P. et al. (2003) Nature Reviews Immunol. 3:813. 
  3. de la Fuente, M.A. et al. (1997) Blood. 90:2398.
  4. Martin, M. et al. (2000) 167:3668.
  5. Tangye, S.G. et al. (2003) J. Immunol. 171:2485.
  6. Tangye, S.G. et al. (2002) Eur. J. Immunol. 32:1640.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CD84/SLAMF5 Antibody (MAB1855)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow, WB.


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(1)
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Bioinformatics

Gene Symbol CD84
Entrez
Uniprot