COX17 Antibody

Product Discontinued

COX17 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to the N-terminal of Human Cox-17.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: COX17
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of COX17 (N8) pAb in extracts from HeLa cells.
  Immunohistochemistry (IHC) analyzes of COX17 (N8) pAb in paraffin-embedded human liver carcinoma tissue.
• Theoretical MW: 7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for COX17 Antibody

• COX17 (yeast) homolog, cytochrome c oxidase assembly protein
• COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
• cytochrome c oxidase assembly protein (S. cerevisiae)
• cytochrome c oxidase assembly protein (yeast)
• cytochrome c oxidase copper chaperone
• human homolog of yeast mitochondrial copper recruitment
• MGC104397
• MGC117386

Background

Cytochrome c oxidase 17 (COX17) is a nuclear gene encoding an assembly protein necessary for proper COX apoenzyme-dependent mitochondrial respiration. The mammalian COX apoenzyme is a heteromer consisting of three mitochondrial genes that encode catalytic subunits and several nuclear genes that encode structural subunits. COX17 influences the recruitment of copper to the mitochondria for incorporation into the COX apoenzyme.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for COX17 Antibody (NBP1-19696)(2)

Publications using NBP1-19696

• Helman A, Klochendler A, Azazmeh N, Gabai Y. p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion. Nature medicine. 2016-03-07 [PMID: 26950362] (IHC-P, Mouse)
• Cai H, Peng F. Knockdown of copper chaperone antioxidant-1 by RNA interference inhibits copper-stimulated proliferation of non-small cell lung carcinoma cells. Oncol Rep 2013-07-01 [PMID: 23624903] (WB, IHC-P, Human)

Bioinformatics

• Gene Symbol: COX17
• Entrez:
  • 10063(Human)
  • 12856(Mouse)
  • 89786(Rat)
• Uniprot:
  • Q14061(Human)