COX17 Antibody (4G2)

Western Blot: COX17 Antibody (4G2) [NBP1-69873] - COX17 monoclonal antibody clone 4G2. Western blot of COX17 expression in IMR-32.

Immunohistochemistry-Paraffin: COX17 Antibody (4G2) [NBP1-69873] - Analysis of anti-COX17 antibody with human brain, cortex at concentration 5 ug/ml.

Immunohistochemistry-Paraffin: COX17 Antibody (4G2) [NBP1-69873] - Analysis of anti-COX17 antibody with human breast at concentration 5 ug/ml.

ELISA: COX17 Antibody (4G2) [NBP1-69873] - Detection limit for recombinant GST tagged COX17 is approximately 0.03 ng/ml as a capture antibody.

Product Discontinued

COX17 Antibody (4G2) Summary

• Immunogen: COX17 (NP_005685, 1 aa - 64 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: COX17
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for COX17 Antibody (4G2)

• COX17 (yeast) homolog, cytochrome c oxidase assembly protein
• COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
• cytochrome c oxidase assembly protein (S. cerevisiae)
• cytochrome c oxidase assembly protein (yeast)
• cytochrome c oxidase copper chaperone
• human homolog of yeast mitochondrial copper recruitment
• MGC104397
• MGC117386

Background

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COX17
• Entrez:
  • 10063(Human)
• Uniprot:
  • Q14061(Human)