COPS8 Antibody - BSA Free

Western Blot: COPS8 Antibody [NBP1-76373] - Human liver lysate with COPS8 antibody at 2 ug/ml.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

COPS8 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit COPS8 Antibody - BSA Free (NBP1-76373) is a polyclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human CSN8. The immunogen is located within the last 50 amino acids of CSN8. Amino Acid Squence: PLSEPAPVPPIPNEQ
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: COPS8
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 2 ug/ml
• Control Peptide:

  COPS8 Peptide (NBP1-76373PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for COPS8 Antibody - BSA Free

• COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
• COP9 homolog
• COP9 signalosome complex subunit 8
• COP9
• CSN8JAB1-containing signalosome subunit 8
• hCOP9
• MGC1297
• MMMEP
• SGN8MGC43256
• Signalosome subunit 8

Background

The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COPS8
• Uniprot:
  • NP_006701(Human)